New England Patriots (5-2) at Buffalo Bills (2-5)
The Patriots are favored by 13.5 points on the road in this game in Buffalo, the most a team has been favored by on the road since the Patriots were 14-point favorites in Jacksonville in week 16 of 2012. The rarity of this kind of line of not a reason not to take the Patriots though. In fact, teams are 15-12 ATS as road favorites of 13.5 or more in the past 30 years. That’s not a reason to take the Patriots necessarily, but historically speaking when a team is favored by this many on the road, there’s a good reason for it.
There is certainly a good reason for it in this one, as the Bills are inarguably the worst team in the league with street free agent Derek Anderson under center, while the Patriots have seemingly hit their stride like they always do and should be considered one of the top few teams in the league. I can’t be confident in the Patriots because they are without injured running back Sony Michel and could also be without tight end Rob Gronkowski for the second straight week and because they could sleepwalk through this game a little bit with a tougher game against the Packers on a short week on deck, but even at less than 100% on the road the Patriots could still win this game by two touchdowns.
New England Patriots 27 Buffalo Bills 13
Pick against the spread: New England -13.5