Indianapolis Colts (2-2) at Kansas City Chiefs (4-0)

The Colts lost at home to the Raiders last week, but that wasn’t all that surprising. Not only did the Colts have this huge game in Kansas City looming as a potential distraction, but they also were without some of their best players like wide receiver TY Hilton, linebacker Darius Leonard, and safety Malik Hooker. The Colts aren’t much healthier this week either. Hilton looks likely to return, but at less than 100%, and their other starting safety Clayton Geathers is also out with injury. 

This line has shifted from Kansas City -8 on the early line last week to Kansas City -11 this week, but I think that’s justified given the players the Colts are missing and how they looked without them last week. In fact, I’m taking the Chiefs, who have won 5 of 9 home games with Pat Mahomes as the starter by 11 points or more. This is one of my lowest confidence picks of the week though, as I think this line is about right.

Kansas City Chiefs 34 Indianapolis Colts 22

Pick against the spread: Kansas City -11

Confidence: None