San Francisco 49ers (5-10) at Los Angeles Rams (11-4)
The Rams are another team that will be resting key players this week, including quarterback Jared Goff, running back Todd Gurley, offensive linemen John Sullivan and Andrew Whitworth, and wide receivers Cooper Kupp and Robert Woods. They haven’t confirmed any defensive players they will be resting, but it stands to reason that they will be sitting at least some key players on that side of the ball, including possibly Defensive Player of the Year candidate (favorite?) Aaron Donald. They won’t be able to rest everyone, as they’ll need 46 players active on game day, but the Rams are locked into either the 3rd or the 4th seed, so this isn’t a particularly meaningful game for them.
As a result, this line has shifted to San Francisco -4 in Los Angeles. That seems about right and I have no interest in betting this game either way because it’s tough to evaluate backups playing in a meaningless game. For pick ‘em purposes, I would take the 49ers, who have obviously been playing much better football in recent weeks, thanks to the emergence of quarterback Jimmy Garoppolo and rookies Reuben Foster and Ahkello Witherspoon on defense, but this is a no confidence pick.
San Francisco 49ers 24 Los Angeles Rams 19
Pick against the spread: San Francisco -4