San Francisco 49ers at Buffalo Bills: 2016 Week 6 NFL Pick

San Francisco 49ers (1-4) at Buffalo Bills (3-2)

The Bills have bounced back in a big way from an 0-2 start. After losing at home to the Jets on Thursday Night week 2, the Bills fired offensive coordinator Greg Roman, which appeared to be a desperation move at the time. With upcoming games against the Cardinals and Patriots, an 0-4 start and a Rex Ryan firing seemed likely. Instead, the Bills ripped off 3 straight wins, beating the Cardinals and the Patriots and then the Rams last week. Now they host the lowly 49ers with a good shot to improve to 4-2.

The question is whether or not they deserve to be favored by 9 points here. The 49ers have one of the worst rosters in the league, especially without middle linebacker NaVorro Bowman and cornerback Jimmie Ward, but the Bills rank just 23rd in first down percentage and probably shouldn’t be favored by this many points against anyone, especially with stud defensive lineman Marcell Dareus missing his 6th straight game thanks to a combination of suspension and injury. I can’t be confident in the 49ers, but they’re the pick here.

Buffalo Bills 20 San Francisco 49ers 13

Pick against the spread: San Francisco +9

Confidence: Low

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