Indianapolis Colts (0-1) at Washington Redskins (1-0)

Coming into the season, I had the Colts as one of the worst teams in the league. They get Andrew Luck back from injury, but have arguably the worst supporting cast in the league around him, including arguably the worst defense in the league. Making matters worse, the Colts will be without two of their better players in this game, Anthony Castonzo, a long-time above average left tackle who will miss his 2nd straight game to open the season, and defensive tackle Denico Autry, a free agent acquisition who played great in the opener, but suffered an ankle injury in practice that will cause him to miss this game.

The Colts lost their opener at home to the Bengals, a game in which the Colts had a -10.23% first down rate differential (3rd worst of the week), and now they head to Washington where the Redskins are coming off of a dominant road victory in Arizona, where they had a +14.59% first down rate differential (2nd best of the week). After an injury plagued 7-9 season in 2017, the Redskins are healthy again in 2018 and are a talented team. They might not make the playoffs in the tough NFC, but they should be able to cover this 5.5 point line at home against a team that should finish near the bottom of the weaker AFC. This is my Pick of the Week.

Washington Redskins 27 Indianapolis Colts 16

Pick against the spread: Washington -5.5

Confidence: Pick of the Week