Los Angeles Rams at Seattle Seahawks: 2025 Week 16 NFL Pick

Los Angeles Rams (11-3) at Seattle Seahawks (11-3)

Both of these teams are 11-3, but the Rams have a significant edge in first down rate differential, +7.71% vs +5.54%, which is much more predictive than win/loss record. The Seahawks have a slight edge in yards per play differential, +1.51 vs. +1.23, but first down rate differential is more predictive. The Rams have also faced a tougher schedule overall and, in terms of schedule adjusted efficiency, which weights first down rate differential higher than yards per play differential, the Rams have about a 4 point edge over the Seahawks.

The Rams are on the road in this game, but they have limited homefield advantage in Los Angeles anyway and, as a result, have consistently outperformed the spread on the road since relocating in 2017, going 46-37 with a +1.4 per game differential against the spread. I like the Rams for at least a small bet in this game, with the Rams just needing to win to cover the spread. Depending on whether or not questionable players play (wide receiver Davante Adams and interior defender Braden Fiske for the Rams, and left tackle Charles Cross for the Seahawks), I would consider increasing this bet.

Update: Charles Cross has been ruled out for the Seahawks, which is a huge loss for their offense. Despite that, this line has shifted to +1.5. I like the money line more than the spread, but this is a high confidence pick either way. Davante Adams is likely to be out for the Rams, but I was being conservative with my original pick and factoring his absence into the equation and not Cross’ absence. I am also considering this for Pick of the Week.

Final Update: After further consideration of this weekend’s games, this is my Pick of the Week at +1.5.

Los Angeles Rams 27 Seattle Seahawks 23 Upset Pick +105

Pick against the spread: LA Rams +1.5

Confidence: Pick of the Week

2025 Week 15 NFL Picks

Pick of the Week

PHI 20 LV 13 (+11.5)

High Confidence Picks

TB 24 ATL 23 (+6)

CIN 30 (+3) BAL 27 Upset Pick +130

NO 23 (+3) CAR 20 Upset Pick +130

SEA 26 IND 17 (+14)

HOU 20 ARZ 13 (+10.5)

Medium Confidence Picks

CHI 22 CLE 17 (+7.5)

SF 28 (-12) TEN 13

Low Confidence Picks

JAX 24 (-13) NYJ 9

LAR 34 (-5.5) DET 27

PIT 27 (-3) MIA 23

KC 24 LAC 20 (+6)

No Confidence Picks

BUF 24 NE 23 (+1.5)

NYG 23 (-2.5) WAS 20

DAL 26 MIN 21 (+6.5)

GB 24 DEN 23 (+2.5)

Atlanta Falcons at Tampa Bay Buccaneers: 2025 Week 15 NFL Pick

Atlanta Falcons (4-9) at Tampa Bay Buccaneers (7-6)

The Buccaneers are 7-6, but they rank 27th in yards per play differential (-0.64) and 23rd in first down rate differential (-1.88%), which are much more predictive than win/loss record. Their record is largely the result of going 5-0 in games decided by 3 points or fewer and they have just two wins by more than 3 points, which is relevant, with this line at 4.5. The Falcons are only 4-9 and might seem like the kind of team that the Buccaneers can beat by more than 5 points, but they have been much better than their record in yards per play differential, ranking 11th at +0.21, and first down rate play differential, ranking 14th at +0.31%. The Falcons are worth a bet and, if the line stays around the same and either left tackle Tristan Wirfs or wide receiver Mike Evans do not return for the Buccaneers, I would make this an even bigger bet.

Early Locked Bets: NO +3, CIN +3, LV +11.5

Update: Evans and Wirfs are playing, but Evans may be on a pitch count and the Buccaneers are also missing tight end Cade Otton and safety Tykee Smith. Despite that, this line has moved up to 6. I am upping this to a high confidence bet.

Tampa Bay Buccaneers 24 Atlanta Falcons 23

Pick against the spread: Atlanta +6

Confidence: High

2025 Week 14 NFL Picks

Pick of the Week

LAR 34 (-8) ARZ 17

High Confidence Picks

GB 31 (-6.5) CHI 20

BUF 34 CIN 31 (+6.5)

TB 23 NO 20 (+8.5)

Medium Confidence Picks

IND 23 (-1.5) JAX 20

LAC 20 (+2.5) PHI 17 Upset Pick +120

DET 28 DAL 27 (+3.5)

Low Confidence Picks

MIN 24 (+1.5) WAS 23 Upset Pick +105

SEA 25 ATL 20 (+7)

DEN 20 LV 13 (+8.5)

MIA 24 NYJ 23 (+3)

No Confidence Picks

KC 21 (-3.5) HOU 16

CLE 14 (-3.5) TEN 9

BAL 22 PIT 17 (+6)

Detroit Lions at Dallas Cowboys: 2025 Week 14 NFL Pick

Dallas Cowboys (6-5-1) at Detroit Lions (7-5)

The Cowboys started the season 3-5-1, but they have won their last three games since their bye week in impressive fashion, blowing out the Raiders and then pulling upsets over the Eagles and Chiefs. The Cowboys have had an explosive offense all season, ranking 3rd in both yards per play and in first down rate on the season, while their defense, which was a huge problem before the bye, has been significantly better since adding Quinnen Williams and Logan Wilson via trade and getting safety Donovan Wilson, safety Malik Hooker, linebacker DeMarvion Overshown, and cornerback Shavon Revel back from injury.

Expecting the Cowboys’ big turnaround on defense, I have made the Cowboys my Pick of the Week in each of the past three weeks. Unfortunately, the secret is now out that they are much better than they were earlier in the season, so we aren’t getting as much line value with them as we used to, but I think there is still a little bit more value to be had with them. This week, they are 3-point underdogs in Detroit against a Lions team that is going in the opposite direction, losing 4 of their last 7 after a 4-1 start, in large part due to injuries, particularly tight end Sam LaPorta, guard Christian Mahogany, and safety Kerby Joseph, a trio of talented starters. The Lions could also be without top wide receiver Amon-Ra St. Brown, starting center Graham Glasgow, and fill-in guard Kayode Awosika this week, as all three are legitimately questionable.

That being said, I don’t think the Cowboys are quite worth betting, mostly due to the Lions’ history after a loss in the Dan Campbell era, as they are 22-10 ATS in that spot since he took over in 2021, outperforming the spread by an average of 3.9 points or game, including a 3-1 ATS record off of a loss this season. The Cowboys are still my pick for pick ‘em purposes, but that strong trend working against them is enough to deter me from betting on them.

Update: This line has increased to 3.5. That is probably due to optimism that Amon-Ra St. Brown is playing, but he will undoubtedly be limited if he does play and I already factored in him playing at less than 100% into my calculated line, so that doesn’t change anything for me. I am a lot more comfortable betting the Cowboys at +3.5 than +3 and if St. Brown happens to not play this line will look like a steal. I am putting a small play on the Cowboys for now and would increase it depending on final inactives and/or where this line ends up.

Detroit Lions 28 Dallas Cowboys 27

Pick against the spread: Dallas +3.5

Confidence: Medium

2025 Week 13 NFL Picks

Pick of the Week

DAL 26 (+3.5) KC 24 Upset Pick +140

High Confidence Picks

BAL 30 CIN 27 (+7)

PHI 23 CHI 20 (+7)

GB 24 (+3) DET 20 Upset Pick +125

LAC 17 LV 10 (+10)

NE 23 NYG 20 (+7.5)

LAR 27 (-9.5) CAR 13

Medium Confidence Picks

NA

Low Confidence Picks

IND 19 (-3) HOU 13

SF 24 CLE 20 (+5.5)

ATL 23 (-2.5) NYJ 20

BUF 23 PIT 21 (+3)

No Confidence Picks

SEA 21 (-11.5) MIN 9

MIA 28 NO 24 (+5.5)

JAX 26 TEN 20 (+6.5)

TB 24 ARZ 20 (+4.5)

DEN 26 (-5.5) WAS 20

New York Giants at New England Patriots: 2025 Week 13 NFL Pick

New York Giants (2-10) at New England Patriots (10-2)

The Giants have a 2-10 record and the Patriots have a 10-2 record, but the Giants have five losses by one score, despite facing arguably the toughest schedule in the league, while the Patriots have six wins by one score, despite facing arguably the easiest schedule in the league. In terms of schedule adjusted efficiency, I only have a 4.5-point gap between these two teams and these two teams are even closer than that suggests in their current state.

The Patriots have been relatively injury free this season, but will be without a pair of starting offensive linemen in Will Campbell and Jared Wilson as well as talented interior defender Milton Williams in this game, which is the most injuries they have had at any one point this season. Meanwhile the Giants have dealt with a lot of injuries this season and are relatively healthy this week, with quarterback Jaxson Dart, running back Tyrone Tracy, offensive tackles Andrew Thomas and Jermaine Eleumunor, center John Michael Schmitz, safeties Jevon Holland and Tyler Nubin, and cornerbacks Paulson Adebo and Cor’Dale Flott all in the lineup after missing time earlier this season. My calculated line has the Patriots only favored by 3.5 points here at home, so we are getting great line value with the Giants as 7.5 point underdogs. This should be another close game for two teams that have played a lot of close games this season.

New England Patriots 23 New York Giants 20

Pick against the spread: NY Giants +7.5

Confidence: High

Las Vegas Raiders at Los Angeles Chargers: 2025 Week 13 NFL Pick

Las Vegas Raiders (2-9) at Los Angeles Chargers (7-4)

This line, favoring the Chargers by 10 points, is too high. The Chargers’ offense has been significantly worse this season in games in which their top offensive lineman Joe Alt doesn’t play the whole game, scoring 19.9 points per game, as opposed to 26.8 when he does play. The Raiders have a terrible offense, but their defense has actually been pretty solid this season, ranking 12th in yards per play allowed and 7th yards per play allowed, so they should be able to hold the Chargers to a pretty low point total, which should allow the Raiders to keep this game close as big underdogs.

When these two teams met earlier this season, the Chargers only won 11, but that was with Alt, in a game in which the Raiders did not have stud tight end Brock Bowers at full strength. The Chargers were on the road in that game and now are at home, but that doesn’t really benefit them, as they are 35-34 (29-36 ATS) at home since moving to Los Angeles in 2017, as opposed to 39-36 (40-31 ATS) on the road. It is very likely there will be more Raiders fans in the crowd than Chargers fans. The Raiders are worth a big bet this week at +10 and are worth a bet at +9.5 as well.

Los Angeles Chargers 17 Las Vegas Raiders 10

Pick against the spread: Las Vegas +10

Confidence: High

Los Angeles Rams at Carolina Panthers: 2025 Week 13 NFL Pick

Los Angeles Rams (10-2) at Carolina Panthers (6-6)

The Rams are currently the slight Super Bowl favorite, but they actually may still be a little underrated, as I think they are clearly the best team in the league. They rank 3rd in yards per play differential (+1.05), 1st in first down rate differential (+6.22%) and 1st in my schedule adjusted efficiency rank. My roster rankings have them as even better than that, ranking them close to 3 full points above any other team in the league. 

They are favored by 10 points on the road in Carolina, but this line should be even higher, especially considering the Panthers are missing two of their top-3 cornerbacks, a starting safety, two of their top-3 linebackers, and a pair of starting offensive linemen due to injuries and suspension. My calculated line is Rams -13.5, giving us enough line value for the Rams to be worth betting at -10. This isn’t a big play, but the Rams are 8-3 ATS this season and I think there is still some line value with them. They should be able to get their 7th double digit victory of the season.

Update: Some -9.5s have showed up this morning. I would do a bigger bet at that number.

Los Angeles Rams 27 Carolina Panthers 13

Pick against the spread: LA Rams -9.5

Confidence: High

Green Bay Packers at Detroit Lions: 2025 Week 13 NFL Pick

Green Bay Packers (7-3-1) at Detroit Lions (7-4)

The Lions managed to come back and beat the Giants in overtime last week, but now they are in a very tough spot, as teams are just 7-25 ATS all-time on Thursdays after playing in an overtime game the previous week. That trend is powerful enough that betting against teams in that spot is almost an auto-bet, unless there is a good reason not to. In this case, there is not, as we would be getting some line value with the Packers as 3-point road underdogs even without that trend being taken into account.

This line suggests that the Lions are a slightly better team to the Packers, but they trail the Packers significantly in first down rate differential (+4.53% vs. +2.36%), while only leading the Packers slightly in yards per play differential (+1.02 vs. +0.93). The Packers are also the healthier team, while the Lions are missing key players like tight end Sam LaPorta, safety Kerby Joseph, and guard Christian Mahogany.  I like them a lot as field goal underdogs and would bet them at +2.5 as well.

Green Bay Packers 24 Detroit Lions 20 Upset Pick +125

Pick against the spread: Green Bay +3

Confidence: High