2025 Week 1 NFL Picks

131-85 ATS on Medium Confidence or Higher (Money Picks) in 2023-2024, 57.3% ATS all-time

Pick of the Week

DEN 20 TEN 17 (+8.5)

High Confidence Picks

NYJ 19 (+3) PIT 17 Upset Pick +130

ARZ 27 (-6.5) NO 13

Medium Confidence Picks

JAX 31 (-3.5) CAR 24

SF 24 (-1) SEA 20

IND 20 (-1) MIA 16

LV 26 (+2.5) NE 24 Upset Pick +125

MIN 27 (-1) CHI 23

Low Confidence Picks

CIN 24 CLE 20 (+5.5)

BAL 30 (-1) BUF 27

TB 27 (PK) ATL 24

KC 24 (-3) LAC 17

PHI 27 (-7.5) DAL 17

No Confidence Picks

WAS 27 (-6) NYG 20

LAR 20 HOU 17 (+3.5)

GB 27 (-2) DET 24

Los Angeles Chargers vs. Kansas City Chiefs: 2025 Week 1 NFL Pick

Los Angeles Chargers (0-0) vs. Kansas City Chiefs (0-0) in Brazil

The Chiefs won 15 games and made the Super Bowl a year ago, but they didn’t have a lot of wins by big margins, with just three of their 17 victories coming by more than 10 points, six coming by more than 7 points, and six coming by 3 points or fewer, relevant considering this line is Kansas City -3. Including their three losses, just over half (11) of the twenty games the Chiefs played last season resulted in them winning by more than 3 points. 

There is potential for the Chiefs to win more games by bigger margins this season once their receiving corps gets to full strength, but they are going to be without their eventual #1 receiver Rashee Rice for the first six games of the season due to suspension. Rice missed most of last season with injury, but it’s worth noting that if you exclude the four games he played last season, the Chiefs won by more than 3 points in exactly half of their games, 8 out of 16. On top of that, the Chiefs have also lost talented guard Joe Thuney and top safety Justin Reid from last year’s team, though the addition of rookie left tackle Josh Simmons should somewhat offset the loss of Thuney.

Given all of that, it wouldn’t be wise to confidently bet the Chiefs as 3-point favorites in a neutral site against a decent Chargers team. My calculated line is exactly where the actual line is at -3. One thing working in the Chiefs’ favor is that the better team tends to cover in international games as they tend to be better prepared for the unusual circumstances, leading to favorites being 37-20 ATS in international games all time. However, I don’t think that is enough to be confident in the Chiefs covering this spread. The Chiefs are my pick for pick ‘em purposes, but this is a low confidence pick.

Kansas City Chiefs 24 Los Angeles Chargers 17

Pick against the spread: Kansas City -3

Confidence: Low

Dallas Cowboys at Philadelphia Eagles: 2025 Week 1 NFL Pick

Dallas Cowboys (0-0) at Philadelphia Eagles (0-0)

The Eagles are defending Super Bowl Champions at home in the first game of the season, which tends to be a good spot for teams, going 13-6-1 ATS since 2005. Unfortunately, we have lost significant line value in the last week, with this line moving from Philadelphia -6.5 to -7.5 in the wake of the Micah Parsons trade. Losing Parsons will be a huge loss for the Cowboys, but he was unlikely to play a significant snap count in this game and might not have played at all after a monthlong holdout, so that line movement, crossing over a key number of 7, seems like an overreaction.

As much as Parsons being traded is a big deal, the Eagles lost a lot this off-season as well and are unlikely to be as good as they were down the stretch last season as a result, particularly on defense, where five of the eleven players who played at least 500 snaps for them are no longer with the team, after being a league best unit in 2024. I am still taking the Eagles for pick ‘em purposes, but I can’t bet them confidently as long as the line is a touchdown or more.

Philadelphia Eagles 27 Dallas Cowboys 17

Pick against the spread: Philadelphia -7.5

Confidence: Low