2025 Week 12 NFL Picks

Pick of the Week

DAL 25 (+3.5) PHI 20 Upset Pick +145

High Confidence Picks

IND 26 (+3.5) KC 24 Upset Pick +155

SEA 26 (-11.5) TEN 10

Medium Confidence Picks

LAR 31 (-6.5) TB 22

NE 33 CIN 28 (+7.5)

Low Confidence Picks

JAX 24 ARZ 23 (+3)

LV 13 CLE 10 (+4)

BAL 28 (-13.5) NYJ 13

SF 31 CAR 24 (+7.5)

CHI 23 PIT 21 (+3)

DET 28 NYG 16 (+14)

No Confidence Picks

BUF 25 HOU 20 (+5.5)

GB 19 MIN 13 (+6.5)

NO 21 ATL 20 (+2.5)

Buffalo Bills at Houston Texans: 2025 Week 12 NFL Pick

Buffalo Bills (7-3) at Houston Texans (5-5)

The Texans are 5-5, but most of their wins have been by multiple scores, while most of their losses have been by one-score, giving them a +57 point differential (9th in the NFL), a +1.43% first down rate differential (9th), and a +0.53 yards per play differential (8th). The Bills have two more wins than them, but aren’t much better in most of those metrics, ranking 8th in point differential (+63), 6th in first down rate differential (+3.07%), and 7th in yards per play differential (+0.68). However, the Texans are without starting quarterback CJ Stroud and stud defensive back Jalen Pitre for the third straight game. This line accurately reflects that though, favoring the Bills by 5.5 at home, which is my exact calculated line. If I have to pick a side, I would pick the Texans, but only for a no confidence pick.

Early Locked Bets: DAL +3.5, IND +3.5

Buffalo Bills 25 Houston Texans 20

Pick against the spread: Houston +5.5

Confidence: None